Anti-GRAP2 APC (Clone : UW40)

Catalogue Number: 30-2528-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Conjugated
Alias:GADS, GRID, GRAP-2, GrbX,GRB2 related adaptor protein 2
Shipping Condition:Blue Ice
Unit(s): 0.1 mg
Host name:
Clone: UW40
Isotype: IgG2a
Immunogen: GST-fusion human GRAP2/GADS protein
Application: FACS

Description

Description: GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.Specificity : The mouse monoclonal antibody UW40 recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.

Additional Text

Gene ID

9402

Gene Name

GRAP2

Purification

Purified

Antibody Clonality

Monoclonal

Storage Note

Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light.