Anti-TIAR Purified

Catalogue Number: 30-2710-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:TIA1 cytotoxic granule associated RNA binding prot TCBP, TIAL1
Shipping Condition:Blue Ice
Unit(s): 0.1 mg
Host name:
Clone: 6E3
Isotype:
Immunogen: GST-tagged recombinant human TIAR
Application: ELISA, FACS, ICC, WB, IHC

Description

Description: TIAR is an ubiquitously expressed RNA-binding protein, which regulates translational control, splicing, and other activities, including apoptosis. TIAR attenuates CDK1 activity, and is essential for the G2/M checkpoint. It accumulates in nuclear foci in late G2 phase and prophase in cells under replication stress. In steady state TIAR shuttles between the cytoplasm and the nucleus, probably as a part of nucleocytoplasmic transport of mRNA, but under stress conditions it accumulates mRNA molecules in granules and prevents their translation. Nucleolytic activity of TIAR against attacked target cells of cytotoxic lymphocytes has also been reported. Similarly, e.g. in permeabilized thymocytes TIAR triggers DNA fragmentation.Specificity :The mouse monoclonal antibody 6E3 recognizes TIAR, an ubiquitously expressed approximately 42 kDa intracellular RNA-binding protein.

Additional Text

Gene ID

7073

Gene Name

TIAL1

Storage Note

Store at 2-8°C. Do not freeze.

Uniprot ID

Q01085

Purification

Protein A purified

Antibody Clonality

Monoclonal

Application Notes

Flow cytometry: Intracellular staining; recommended dilution: 5 µg/ml