Anti-TIAR Purified
Catalogue Number: 30-2710-ABO
| Manufacturer: | Abeomics |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | TIA1 cytotoxic granule associated RNA binding prot TCBP, TIAL1 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 0.1 mg |
| Host name: | |
| Clone: | 6E3 |
| Isotype: | |
| Immunogen: | GST-tagged recombinant human TIAR |
| Application: | ELISA, FACS, ICC, WB, IHC |
Description
Description: TIAR is an ubiquitously expressed RNA-binding protein, which regulates translational control, splicing, and other activities, including apoptosis. TIAR attenuates CDK1 activity, and is essential for the G2/M checkpoint. It accumulates in nuclear foci in late G2 phase and prophase in cells under replication stress. In steady state TIAR shuttles between the cytoplasm and the nucleus, probably as a part of nucleocytoplasmic transport of mRNA, but under stress conditions it accumulates mRNA molecules in granules and prevents their translation. Nucleolytic activity of TIAR against attacked target cells of cytotoxic lymphocytes has also been reported. Similarly, e.g. in permeabilized thymocytes TIAR triggers DNA fragmentation.Specificity :The mouse monoclonal antibody 6E3 recognizes TIAR, an ubiquitously expressed approximately 42 kDa intracellular RNA-binding protein.
Additional Text
Gene ID
7073
Gene Name
TIAL1
Storage Note
Store at 2-8°C. Do not freeze.
Uniprot ID
Q01085
Purification
Protein A purified
Antibody Clonality
Monoclonal
Application Notes
Flow cytometry: Intracellular staining; recommended dilution: 5 µg/ml
30-2710 Datasheet
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