Anti-PPM1D Purified

Catalogue Number: 30-2720-ABO

Manufacturer:Abeomics
Type:Monoclonal Primary Antibody - Unconjugated
Alias:protein phosphatase, Mg2+/Mn2+ dependent 1D WIP1, Protein phosphatase 1D, JDVS, WIP1, IDDGIP
Shipping Condition:Blue Ice
Unit(s): 0.1 mg
Host name:
Clone: 7E11/C5
Isotype:
Immunogen: Purified human PPM1D
Application: ELISA, ICC, WB, IHC

Description

Description: PPM1D is a Mg2+/Mn2+ dependent protein phosphatase 1D with inducible expression in response to various types of environmental stress. This expression is p53-dependent, and subsequently PPM1D negatively regulates the p53-mediated transcription, thus it suppresses the apoptosis. PPM1D contributes to development of carcinomas, and seems to be a promissing therapeutic target. Amplification of PPM1D is associated with breast cancer.Specificity :The mouse monoclonal antibody 7E11/C5 recognizes an epitope within the sequence FTNEDELYNLLTDSP of PPM1D, a protein phosphatase, which contributes to development of some carcinomas.

Additional Text

Gene ID

8493

Gene Name

PPM1D

Uniprot ID

O15297

Storage Note

Store at 2-8°C. Do not freeze.

Purification

Protein A purified

Antibody Clonality

Monoclonal

Application Notes

Western blotting: Recommended dilution: 1-2 µg/ml.