Polyclonal Antibody to Histone H2A.X (Phospho-Ser139)

Catalogue Number: 35-1247-ABO

Manufacturer:	Abeomics
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	H2A.X\|\| H2AFX\|\| H2a/x\|\| HIST5-2AX
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 50 ug
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Peptide sequence around phosphorylation site of serine 139 (Q-A-S(p)-Q-E) derived from Human Histone H2A.X.
Application:	IF, WB

Overview
Datasheets

Description

Description: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation. Yaneva M, et al. (2005) Nucleic Acids Res. 33(16): 5320-5330. Tsukuda T, et al.(2006) Nature. Author manuscript; available in PMC 2006 March 6.

Additional Text

Gene ID

3014

Uniprot ID

P16104

Gene Name

H2ax

Antibody Clonality

Polyclonal

Application Notes

Predicted MW: 15kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

35-1247 Datasheet

35-1247 MSDS

Price

£449.00

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