Polyclonal Antibody to NF-kB-p105/p50 (Ab-893)
Catalogue Number: 35-1375-ABO
35-1375 Image
35-1375 Image
35-1375 Image
Figure 1: Western blot analysis of extracts from 293 cells using NF-kB-p105(Ab-893) Antibody 35-1375 .
35-1375 Image
Figure 2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NF-kB-p105(Ab-893) Antibody 35-1375 (left) or the same antibody preincubated with blocking peptide(right).
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | DNA-binding factor KBF1|| EBP-1|| NF-kappa-B1 p84/NF-kappa-B1 p98|| NF-kB1|| NF-kB-p50 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Peptide sequence around aa.891~895 (A-S-S-P-V) derived from Human NF-kB-p105. |
| Application: | WB, IHC |
Description
Description: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NF-kB1/p105, NF-kB1/p50, REL and NF-kB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. Hou S, et al. (2003) J Biol Chem. 278(46): 45994-45998. Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179. Baeuerle P A, et al. (1996) Cell 87:13-20. Haskill S, et al. (1991) Cell 65:1281-1289.
Additional Text
Antibody Clonality
Polyclonal
Application Notes
Predicted MW: 120 kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Storage Note
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
35-1375 Datasheet
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