Polyclonal Antibody to Myc (Ab-358)

Catalogue Number: 35-1392-ABO

Manufacturer:	Abeomics
Type:	Tag antibodies
Alias:	C-Myc
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 50 ug
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Peptide sequence around aa.356~360 (R-R-T-H-N) derived from Human Myc.
Application:	WB, IHC

Overview
Datasheets

Description

Description: Myc proto-oncogene encodes nuclear DNA-binding phosphoproteins that are involved in the regulation of gene expression and DNA replication during cell growth and differentiation. Myc encodes a protein of 65 kDa which is expressed in almost all normal and transformed cells. The expression correlates with the proliferation state of the cells. Transcription is repressed in quiescent or terminally differentiated cells. Expression of Myc is generally induced after mitogenic stimulation of cells or serum induction. Myc therefore is an important positive regulator of cell growth and proliferation. Myc has been demonstrated also to be a potent inducer of apoptosis when expressed in the absence of serum or growth factors. Apoptosis may serve also as a protective mechanism to prevent tumorigenicity elicited by deregulated Myc expression. Sequences of the Myc oncogene have been highly conserved throughout evolution, from Drosophila to vertebrates.

Additional Text

Gene Name

MYC

Gene ID

4609

Uniprot ID

P01106

Antibody Clonality

Polyclonal

Application Notes

Predicted MW: 60kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

35-1392 Datasheet

35-1392 MSDS

Price

£449.00

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