Polyclonal Antibody to HDAC5 (Ab-498)
Catalogue Number: 35-1490-ABO
35-1490 Image
35-1490 Image
35-1490 Image
Figure 1: Western blot analysis of extracts from 293 and HepG2 cells using HDAC5 (Ab-498) Antibody 35-1490 .
35-1490 Image
Figure 2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HDAC5 (Ab-498) Antibody 35-1490 (left) or the same antibody preincubated with blocking peptide(right).
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | HD5 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Peptide sequence around aa.496~500 (T-Q-S-S-P) derived from Human HDAC5/7. |
| Application: | WB, IHC |
Description
Description: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. Doppler H, et al. (2005) J Biol Chem. 280(15):15013-15019. McKinsey TA, et al. (2000) Nature. 408(6808): 106-111.
Additional Text
Gene Name
HDAC5
Gene ID
10014
Uniprot ID
Q9UQL6
Antibody Clonality
Polyclonal
Application Notes
Predicted MW: 124kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Storage Note
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
35-1490 Datasheet
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