Polyclonal Antibody to IkB- Alpha (Ab-42)
Catalogue Number: 35-1518-ABO
35-1518 Image
35-1518 Image
35-1518 Image
Figure 1: Western blot analysis of extracts from 293 and THP1 cells using IkB-a(Ab-42) Antibody 35-1518 .
35-1518 Image
Figure 2: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkB-a(Ab-42) Antibody 35-1518 (left) or the same antibody preincubated with blocking peptide(right).
| Manufacturer: | Abeomics |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | I-kappa-B-alpha, IkBA, NF-kappaB inhibitor alpha, NF-kBI, NF-kBIA |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Peptide sequence around aa. 40~44 (E-E-Y-E-Q) derived from Human IkB-a. |
| Application: | WB, IHC |
Description
Description: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.
Additional Text
Gene ID
4792
Gene Name
NFKBIA
Uniprot ID
P25963
Antibody Clonality
Polyclonal
Application Notes
Predicted MW: 39kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
Storage Note
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
35-1518 Datasheet
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