Polyclonal Antibody to IkB- Alpha (Ab-42)

Catalogue Number: 35-1518-ABO

Manufacturer:Abeomics
Type:Polyclonal Primary Antibody - Unconjugated
Alias:I-kappa-B-alpha, IkBA, NF-kappaB inhibitor alpha, NF-kBI, NF-kBIA
Shipping Condition:Blue Ice
Unit(s): 100 ug, 50 ug
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: Peptide sequence around aa. 40~44 (E-E-Y-E-Q) derived from Human IkB-a.
Application: WB, IHC

Description

Description: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.

Additional Text

Gene ID

4792

Gene Name

NFKBIA

Uniprot ID

P25963

Antibody Clonality

Polyclonal

Application Notes

Predicted MW: 39kd, Western blotting: 1:500~1:1000, Immunohistochemistry: 1:50~1:100

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.