Polyclonal Antibody to NF-kB-p105/p50 (Ab-927)

Catalogue Number: 35-1634-ABO

Manufacturer:	Abeomics
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	DNA-binding factor KBF1\|\| EBP-1\|\| NF-kappa-B1 p84/NF-kappa-B1 p98\|\| NF-kB1\|\| NF-kB-p50
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 50 ug
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:	Peptide sequence around aa.925~929 (C-D-S-G-V ) derived from Human NF-kB-p105.
Application:	IF, WB

Overview
Datasheets

Description

Description: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NF-kB1/p105, NF-kB1/p50, REL and NF-kB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. Hou S, et al. (2003) J Biol Chem. 278(46): 45994-45998. Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179. Baeuerle P A, et al. (1996) Cell 87:13-20. Haskill S, et al. (1991) Cell 65:1281-1289.

Additional Text

Gene Name

NFKB1

Gene ID

4790

Uniprot ID

P19838

Antibody Clonality

Polyclonal

Application Notes

Predicted MW: 120 kd, Western blotting: 1:500~1:1000, Immunofluorescence: 1:100~1:200

Storage Note

Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.

35-1634 Datasheet

35-1634 MSDS

Price

£449.00

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