Anti-HDAC3 Polyclonal Antibody

Catalogue Number: 39-2121-ABO

Manufacturer:	Abeomics
Shelf Life:	12 months
Type:	Polyclonal Primary Antibody - Unconjugated
Alias:	Histone deacetylase 3; HD3; 3.5.1.98; RPD3-2; SMAP45; HDAC3
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Host name:	Rabbit
Clone:
Isotype:	IgG
Immunogen:
Application:	WB

Overview
Datasheets

Description

Description: HDAC3(HISTONE DEACETYLASE 3) is a member of the histone deacetylase/acuc/apha family of proteins that is an enzyme that in humans is encoded by the HDAC3 gene. The HDAC3 gene is mapped to 5q31.3. HDAC3 has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. The protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. And this gene is regarded as a potential tumor suppressor gene. HDAC3 has an open reading frame of 428 amino acids and shares 53% amino acid identity with HDAC1 and 52% with HDAC2. The catalytic domain of HDAC4 interacts with HDAC3 via the transcriptional corepressor NCOR2. All experimental conditions leading to the suppression of HDAC4 binding to NCOR2 and to HDAC3 resulted in loss of enzymatic activity associated with HDAC4.

Additional Text

Gene Name

HDAC3

Gene ID

8841

Uniprot ID

O15379

Purification

Affinity Purified

Antibody Clonality

Polyclonal

Application Notes

Western blot : 0.1-0.5µg/ml; Immunohistochemistry(Paraffin-embedded Section) : 0.5-1µg/ml

Storage Note

At -20°C for one year. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for a longer time. Avoid repeated freezing and thawing.

39-2121 MSDS

39-2121 Datasheet

Price

£638.00

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