Telaprevir (VX-950)

Catalogue Number: A4031-APE

Manufacturer:	Apexbio
Molecular Formula:	C36H53N7O6
Physical state:	A solid
Type:	Protease Inhibitors
Alias:	VX950, VX 950, MP-424,Telaprevir
Shipping Condition:	Blue Ice
Unit(s):	10 mg, 10 mM (in 1mL DMSO), 2 mg, 25 mg, 5 mg

Overview
Datasheets

Description

Description: Telaprevir (also known as VX-950), derived from the viral NS5A/5B substrate of the protease through structure-based techniques, is a novel and potent inhibitor of hepatitis C virus (HCV) NS3-4A protease, which covalently and reversibly inhibit the NS3-4A protease via a slow-binding and slow-dissociation mechanism. Results of multiple studies show that telaprevir potently inhibits a genotype 1 (H strain) NS3 protease domain plus a NS4A cofactor peptide with the inhibitory constant (Ki) of 7 nM, exhibits strong anti-HCV in HCV replicon cells in vitro, and suppresses HCV replication as well as the emergence of resistance in HCV replicon cells with a synergistic effect with IFN-α.ReferenceKai Lin, Robert B. Perni, Ann D. Kwong, and Chao Lin. VX-950, a novel hepatitis C virus (HCV) NS3-4A protease inhibitor, exhibits potent antiviral activities in HCV replicon cells. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2006; 50(5): 1813-1822

Additional Text

Storage Note

Store at -20°C

Short Description

HCV NS3-4A protease inhibitor

Reagent:Smile String

CCCC(C(=O)C(=O)NC1CC1)NC(=O)C2C3CCCC3CN2C(=O)C(C(C)(C)C)NC(=O)C(C4CCCCC4)NC(=O)C5=NC=CN=C5

Solubility

≥32.95 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

A4031 Datasheet

A4031 CofA

A4031 MSDS

Price

£165.00

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