Atazanavir
Catalogue Number: A8205-APE
| Manufacturer: | Apexbio |
| Molecular Formula: | C38H52N6O7 |
| Physical state: | A solid |
| Type: | Protease Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 10 mM (in 1 ml DMSO), 25 mg, 5 mg, 50 mg, Sample |
Description
Description: Atazanavir is a novel and potent azapeptide protease inhibitor that specifically inhibits the human immunodeficiency virus type 1 (HIV-1) protease enzyme with inhibition constant Ki of 66 nmol/L and also inhibits the viral replication of HIV-1 with 50% effective concentration EC50 ranging from 2.6 to 5.3 nmol/L. Atazanavir binds to HIV-1 protease preventing the cleavage of gag and gag-pol polyproteins, which results in the formation of immature virions in HIV-1-infected cells. Atazanavir has a different C-2 symmetric chemical structure and a generally greater antiretroviral potency in various HIV strains compared to other protease inhibitors, including indinavir, nelfinavir, ritonavir, saquinavir and amprenavir.ReferenceFuster D, Clotet B. Review of atazanavir: a novel HIV protease inhibitor. Expert Opin Pharmacother. 2005 Aug;6(9):1565-72.Croom KF, Dhillon S, Keam SJ. Atazanavir: a review of its use in the management of HIV-1 infection. Drugs. 2009 May 29;69(8):1107-40. doi: 10.2165/00003495-200969080-00009.
Additional Text
Storage Note
Store at -20°C
Short Description
HIV protease inhibitor,highly potent
Reagent:Smile String
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Solubility
≥28.6 mg/mL in DMSO; insoluble in H2O; ≥9.9 mg/mL in EtOH with ultrasonic
A8205 Datasheet
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PRODUCT
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DELIVERY
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