Pitavastatin Calcium

Catalogue Number: A8504-APE

Manufacturer:Apexbio
Molecular Formula:C50H46CaF2N2O8
Physical state:A solid
Type:Enzyme Inhibitors
Shipping Condition:Blue Ice
Unit(s): 10 mg, 10 mM (in 1mL DMSO), 25 mg

Description

Description: Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.

Additional Text

Storage Note

Store at -20°C

Short Description

Enzyme HMGCR inhibitor

Reagent:Smile String

C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]

Solubility

≥34.85 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

Price
£40.00


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