Pitavastatin Calcium
Catalogue Number: A8504-APE
| Manufacturer: | Apexbio |
| Molecular Formula: | C50H46CaF2N2O8 |
| Physical state: | A solid |
| Type: | Enzyme Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 10 mM (in 1mL DMSO), 25 mg |
Description
Description: Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting NADPH oxidase. In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187. Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.
Additional Text
Storage Note
Store at -20°C
Short Description
Enzyme HMGCR inhibitor
Reagent:Smile String
C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.C1CC1C2=NC3=CC=CC=C3C(=C2C=CC(CC(CC(=O)[O-])O)O)C4=CC=C(C=C4)F.[Ca+2]
Solubility
≥34.85 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
A8504 Datasheet
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