Glucokinase (EC 2.7.1.2), Escherichia coli

Catalogue Number: AE00171-NZY

Manufacturer:	NZYTech
Type:	Kinases
Shipping Condition:	RT
Storage Condition:	2-8°C
Unit(s):	1400 units

Overview

Description

Description: Escherichia coli glucokinase (EC 2.7.1.2) is an intracellular enzyme responsible for the phosphorylation of glucose to glucose-6-phosphate using ATP. In contrast to those of vertebrates, glucokinases from bacteria are functionally distinct from hexokinases (EC 2.7.1.1) with respect to their more absolute specificity for glucose. The crystal structure of E. coli glucokinase has been determined (PDB coordinates 1Q18 and 1SZ2), revealing a two domain architecture with the active site located in a deep cleft formed between the two domains. The enzyme reveals a dimeric structure and presents a similar fold to human and yeast hexokinases. The enzyme is provided in 3.2 M ammonium sulphate. Activity: 100 U/ml Temperature and pH optimum/stability: The optimum pH and temperature are 7.5 and 25 °C, respectively.

Additional Text

Short Description

Escherichia coli glucokinase (EC 2.7.1.2) is an intracellular enzyme responsible for the phosphorylation of glucose to glucose-6-phosphate using ATP. The enzyme reveals a dimeric structure and presents a similar fold to human and yeast hexokinases.

Price

£155.00

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