Hydroxychloroquine Sulfate

Catalogue Number: B4874-APE

Manufacturer:	Apexbio
Molecular Formula:	C18H28ClN3O5S
Type:	Enzyme Inhibitors
Shipping Condition:	Blue Ice
Unit(s):	10 mM (in 1mL H2O), 50 mg

Overview
Datasheets

Description

Description: Hydroxychloroquine Sulfate is a synthetic quinine derivative commonly used as an antimalarial drug [1]. It is also useful in managing systemic lupus erythematosus, rheumatoid arthritis, and other diseases. Also acts as an inhibitor of autophagy and toll-like receptor 7/9(TLR7/9) [1-3]. Five micromolar Hydroxychloroquine sulfate or chloroquine also has no measurable effect on intracellular pH, although these concentrations can inhibit TLR9 or 7 signaling induced by DNA or RNA ligands [4]. Hydroxychloroquine sulfate is prescribed for the treatment of lupus, and both Hydroxychloroquine sulfate and its analog chloroquine inhibit TLR7 and 9 signaling [4]. References:[1] Ben-Zvi I, Kivity S, Langevitz P, et al. Hydroxychloroquine: From Malaria to Autoimmunity. Clin. Rev. Allergy Immunol, 2012, 42 (2): 145-153.[2] Yildirim-Toruner C, Diamond B. Current and novel therapeutics in the treatment of systemic lupus erythematosus. Journal of Allergy and Clinical Immunology, 2011, 127 (2): 303-312.[3] Swierkot J, and Szechinski J. Methotrexate in rheumatoid arthritis. Pharmacol. Rep, 2006, 58 (4): 473-492.[4] Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol, 2014, 85 (3): 429-40.

Additional Text

Storage Note

Store at -20°C

Short Description

Autophagy inhibitor

Reagent:Smile String

CCN(CCCC(C)NC1=C2C=CC(=CC2=NC=C1)Cl)CCO.OS(=O)(=O)O

Solubility

insoluble in DMSO; insoluble in EtOH; ≥17.6 mg/mL in H2O

B4874 CofA

B4874 MSDS

Price

£44.00

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