Pseudo-UTP
Catalogue Number: B7972-APE
| Manufacturer: | Apexbio |
| Physical state: | Solution |
| Type: | Labelled Nucleotides |
| Alias: | Pseudouridine-5'-Triphosphate, 5-Ribosyl Uracil |
| Shipping Condition: | Dry Ice |
| Storage Condition: | -20°C/-70°C |
| Unit(s): | 10 ul (100 mM), 100 ul (100 mM), 50 ul (100 mM) |
Description
Description: Pseudo-UTP, also known as pseudouridine-5'-O-triphosphate, is one of the most commonly used modified nucleoside-5'-O-triphosphates. Pseudo-UTP is a building block for the polymerase-mediated synthesis of RNA molecules. RNA molecules, especially messenger RNAs (mRNAs), have widespread applications in therapeutic and diagnostic areas, and have demonstrated their superiority over plasmid DNA techniques in both gene and vaccination therapy. Compared with uridine-containing unmodified mRNAs, the application of pseudouridine-containing modified mRNAs exhibits better nuclease stability, immunogenicity, and translational properties. Thus, pseudo-UTP could be used to develop drugable mRNAs with improved properties, by replacing the standard bases by modified ones. Reference:1. Shanmugasundaram M, Senthilvelan A, Kore AR. Gram-scale chemical synthesis of base-modified ribonucleoside-5'-O-triphosphates. Current Protocols in Nucleic Acid Chemistry, 2016, 67: 13.15.1-13.15.10.
Additional Text
Reagent:Smile String
O=C(NC=C1C2C(O)C(O)C(COP([O-])(OP([O-])(OP([O-])([O-])=O)=O)=O)O2)NC1=O.[Li+].[Li+].[Li+].[Li+]
Storage Note
Store at -20°C or below
Short Description
A modified nucleoside-5'-O-triphosphate, commonly used for drugable mRNA synthesis
Molecular Formula
C9H15N2O15P3 (free acid)
Molecular Weight
484.1 (free acid)
B7972 CofA
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