ddhCTP
Catalogue Number: B8293-APE
| Manufacturer: | Apexbio |
| Molecular Formula: | C9H14N3O13P3 |
| Physical state: | Solution |
| Type: | Labelled Nucleotides |
| Alias: | 3'-deoxy-3',4'-didehydro-CTP |
| Shipping Condition: | Dry Ice |
| Storage Condition: | -20°C/-70°C |
| Unit(s): | 10 ul, 100 ul, 50 ul |
Description
Description: Viperin, a member of the radical S-adenosyl-l-methionine (SAM) superfamily of enzymes, is an interferon-inducible protein implicated in the inhibition of replication of a broad range of RNA and DNA viruses, including dengue virus, West Nile virus, hepatitis C virus, influenza A virus, rabies virus and HIV. Viperin catalyses the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP), a previously undescribed biologically relevant molecule, via a SAMdependent radical mechanism [1].ddhCTP, can be produced in mammalian cytosol, is a chain terminator for the RNA-dependent RNA polymerases from multiple members of the Flavivirus genus, and directly inhibits replication of Zika virus in vivo[1]. Reference:[1] Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo. A naturally occurring antiviral ribonucleotide encoded by the human genome. Nature, 2018; DOI: 10.1038/s41586-018-0238-4.
Additional Text
Solubility
Soluble in H2O
Reagent:Smile String
OC1C=C(COP(OP(OP(O)(O)=O)(O)=O)(O)=O)OC1N2C(N=C(N)C=C2)=O
Short Description
Chain terminator for the RNA-dependent RNA polymerases
Storage Note
Store at -20°C or below
Molecular Formula
C9H14N3O13P3
Molecular Weight
465.14
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