Tyrosine Kinase Receptor Antibody
Catalogue Number: BS-0192R-BSS
bs-0192R Image
bs-0192R Image
bs-0192R Image
bs-0192R Image
bs-0192R Image
Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti Trk A/B/C Polyclonal Antibody, Unconjugated (bs-0192R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
bs-0192R Image
Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti Trk A/B/C Polyclonal Antibody, Unconjugated (bs-0192R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
bs-0192R Image
Lane 1: Human SH-SY5Y cell lysates; Lane 2: Human K562 cell lysates probed withTyrosine Kinase Receptor Polyclonal Antibody, Unconjugated (bs-0192R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
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Lane 1: Mouse Cerebrum lysates; Lane 2: Mouse NIH/3T3 cell lysates; Lane 3: Mouse Large intestine lysates; Lane 4: Mouse Uterus lysates probed with Tyrosine Kinase Receptor Polyclonal Antibody, Unconjugated (bs-0192R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human Trk A |
| Application: | ELISA, ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors. Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.
Additional Text
Gene Name
NTRK1
Gene ID
4914
Uniprot ID
P04629
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Unmodified
Specificity
MTC; TRK; TRK1; TRKA; Trk-A; p14-TrkA; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; gp14trk; NTRK1
Storage Note
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
bs-0192R Datasheet
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PRODUCT
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DELIVERY
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