CXCR3 Polyclonal Antibody
Catalogue Number: BS-0341R-BSS
bs-0341R Image
bs-0341R Image
bs-0341R Image
Mouse muscle lysates probed with CXCR3 Polyclonal Antibody, Unconjugated (bs-0341R) at 1:300 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:10000 for 60 min at 37°C.
bs-0341R Image
Formalin-fixed and paraffin embedded human nasal mucosa tissue labeled with Anti-CXCR3/CD183 Polyclonal Antibody, Unconjugated (bs-0341R) at 1:200, followed by conjugation to the secondary antibody and DAB staining
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | GPR9; MigR; CD182; CD183; Mig-R; CKR-L2; CMKAR3; IP10-R; C-X-C chemokine receptor type 3; CXC-R3; CXCR-3; G protein-coupled receptor 9; Interferon-inducible protein 10 receptor; IP-10 receptor; CXCR3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human CXCR3 isoform 2 |
| Application: | ELISA, FC, ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11.
Additional Text
Gene ID
2833
Uniprot ID
P49682
Gene Name
CXCR3
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
bs-0341R Datasheet
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