Cyclin D2 Polyclonal Antibody
Catalogue Number: BS-1148R-BSS
bs-1148R Image
bs-1148R Image
bs-1148R Image
bs-1148R Image
bs-1148R Image
Image provided by One World Lab validation program. A431 cells probed with Rabbit Anti-Cyclin D2 Polyclonal Antibody (bs-1148R) at 1:200 for 60 minutes at room temperature followed by Goat Anti-Rabbit IgG (H+L) Alexa Fluor 488 Conjugated secondary antibody.
bs-1148R Image
Image provided by One World Lab validation program. A549 cells probed with Rabbit Anti-Cyclin D2 Polyclonal Antibody (bs-1148R) at 1:50 for 60 minutes at room temperature followed by Goat Anti-Rabbit IgG (H+L) Alexa Fluor 488 Conjugated secondary antibody.
bs-1148R Image
Formalin-fixed and paraffin embedded human flat moss tinea tissue labeled with Anti-Cyclin D2 Polyclonal Antibody, Unconjugated (bs-1148R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
bs-1148R Image
Formalin-fixed and paraffin embedded rat ovary labeled with Anti-Cyclin D2 Polyclonal Antibody, Unconjugated (bs-1148R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | MPPH3; KIAK2; G1/S-specific cyclin-D2; CCND2 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic peptide derived from human Cyclin D2 |
| Application: | ELISA, FC, ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Additional Text
Gene Name
CCND2
Uniprot ID
P30279
Gene ID
894
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Modification
Unmodified
Storage Note
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
bs-1148R Datasheet
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