STAT3 (Ser727) Polyclonal Antibody
Catalogue Number: BS-3429R-BSS
bs-3429R Image
bs-3429R Image
bs-3429R Image
bs-3429R Image
Formalin-fixed and paraffin embedded human lung carcinoma labeled with Anti-phospho-STAT3 (Ser727) Polyclonal Antibody, Unconjugated (bs-3429R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.
bs-3429R Image
Paraformaldehyde-fixed, paraffin embedded Rat liver; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with STAT3 (Ser727) Polyclonal Antibody, Unconjugated (bs-3429R) at 1:200 overnight at 4°C, DAB staining.
bs-3429R Image
Lane 1: rat heart lysates Lane 2: rat brain lysates probed with Anti phospho-STAT3(Ser727) Polyclonal Antibody, Unconjugated (bs-3429R) at 1:200 in 4°C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 90min in 37°C. Predicted band 85kD. Observed band size: 85kD.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | APRF; HIES; ADMIO; Signal transducer and activator of transcription 3; Acute-phase response factor; STAT3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 20 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | KLH conjugated synthetic phosphopeptide derived from human STAT3 around the phosphorylation site of Ser727 |
| Application: | ELISA, FC, ICC, IF, IHC-P, WB, IHC-Fr |
Description
Description: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).
Additional Text
Gene Name
STAT3
Gene ID
6774
Uniprot ID
P40763
Modification
Phosphorylated, Ser727
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Polyclonal
Storage Note
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
bs-3429R Datasheet
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