Recombinant SARS-CoV-2 Spike RBD (E417N, E484K, N501Y) Protein, C-His
Catalogue Number: BS-41449P-BSS
BS-41449P Image
BS-41449P Image
BS-41449P Image
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
BS-41449P Image
Measured by its binding ability in a functional ELISA. Immobilized human ACE2, His-Avi Tag (Cat: bs-46001P) at 2µg/ml (100ul/Well) can bind SARS-CoV-2 Spike RBD (K417N, E484K, N501Y), His Tag (Cat: bs-41449P), the EC50 is 15.63ng/ml.
| Manufacturer: | Bioss Inc |
| Type: | Virus Proteins |
| Host Cell: | HEK293 cells |
| Shipping Condition: | Blue Ice |
| Storage Condition: | -70°C |
| Unit(s): | 1 mg, 100 ug |
| Application: | ELISA, SDS-PAGE |
Description
Description: The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to specific receptors on the host cell. The spike is essential for both host specificity and viral infectivity. The spike (S) glycoprotein of coronaviruses is known to be necessary for the binding of the virus to the host cell at the advent of the infection process. It has been reported that SARS-CoV-2 can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor-binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 provides essential elements needed for membrane fusion. The S protein plays vital parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; the Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor-binding domain (RBD), leading to a higher mortality rate.
Additional Text
Gene Name
S
Protein Tag
HIS Tag
Gene ID
43740568
Uniprot ID
P0DTC2
Storage Note
The product should be stored at -70°C or -20°C.
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