Recombinant SARS-COV-2 Spike RBD (N501Y, K417N, E484K) Protein
Catalogue Number: BS-46018P-BSS
BS-46018P Image
BS-46018P Image
BS-46018P Image
BS-46018P Image
Recombinant SARS-CoV-2 Spike RBD (N501Y, K417N, E484K) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
BS-46018P Image
The purity of SARS-CoV-2 Spike RBD is greater than 95% as determined by SEC-HPLC.
BS-46018P Image
Immobilized SARS-CoV-2 Spike RBD (N501Y, K417N, E484K), at 0.5ug/ml (100ul/Well). Dose-response curve for ACE2, hFc tag with the EC50 of 0.48ug/ml determined by ELISA.
| Manufacturer: | Bioss Inc |
| Physical state: | Lyophilized |
| Type: | Spike Proteins |
| Host Cell: | HEK293 cells |
| Shipping Condition: | Blue Ice |
| Storage Condition: | -70°C |
| Unit(s): | 100 ug, 1 mg |
| Application: | ELISA, WB, HPLC |
Description
Description: SARS-CoV-2 exploits angiotensin-converting enzyme 2 (ACE2) as a receptor to invade cells. It has been reported that the UK and South African strains may have higher transmission capabilities, eventually in part due to amino acid substitutions on the SARS-CoV-2 Spike protein. The results of a study show the N501Y replacement in this region of the interface (present in both the UK and South African strains) should be favorable for the interaction with ACE2, while the K417N and E484K substitutions (South African strain) would seem neutral or even unfavorable.
Additional Text
Protein Tag
HIS Tag
Accession Number
QHD43416.1
Storage Note
The product should be stored at -70°C or -20°C.
Short Description
Recombinant SARS-COV-2 Spike RBD (N501Y, K417N, E484K) Protein protein is expressed in HEK293 with His tag. It contains the amino acid sequence of Arg319-Phe541 (N501Y, K417N, E484K).
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