HPV16 E6 protein (2E3) Monoclonal Antibody

Catalogue Number: BSM-0990M-BSS

Manufacturer:	Bioss Inc
Shelf Life:	12 months
Type:	Monoclonal Primary Antibody - Unconjugated
Alias:	Protein E6; E6
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:
Isotype:	IgG
Immunogen:	KLH conjugated synthetic peptide derived from HPV16 E6 protein
Application:	IF, IHC-P

Overview
Datasheets

Description

Description: Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.

Additional Text

Purification

Protein G purified

Uniprot ID

P03126

Gene ID

1489078

Concentration

1 ug/ul

Gene Name

Antibody Clonality

Monoclonal

Modification

Unmodified

Storage Note

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

bsm-0990M Datasheet

Price

£392.00

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