AP-A Monoclonal Antibody
Catalogue Number: BSM-54646R-BSS
BSM-54646R Image
BSM-54646R Image
Paraformaldehyde-fixed, paraffin embedded Human kidney; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with AP-A Monoclonal Antibody, Unconjugated (bsm-54646R) at 1:200 for 30 minutes at room temperature, DAB staining.
| Manufacturer: | Bioss Inc |
| Shelf Life: | 12 months |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Rabbit |
| Clone: | 11B3 |
| Isotype: | IgG |
| Immunogen: | Synthetic Peptide within Human AP-A. |
| Application: | IHC-P, WB, IHC |
Description
Description: Aminopeptidase A, also designated APA, gp160 human kidney differentiation antigen, glutamyl aminopeptidase, or enpep, is a differentiation-related kidney glycoprotein. As a cell surface, zinc-dependent metalloprotease, Aminopepti-dase A specifically cleaves amino-terminal acidic residues from peptide substrates such as Angiotensin II. APA is expressed on the surface of epithelial cells of the glomerulus and proximal tubule cells of the human nephron, where it may mediate the constitutive trafficking of Glut4-containing vesicles. These Glut4-containing vesicles are tissue-specific secretory-like microsomal structures that mediate insulin-dependent translocation of GLUT4 to the cell surface in fat and muscle cells. Mutations in the gp160/APA gene, including loss of protein expression or enzymatic activity, occur in 20% of primary clear cell renal carcinomas.
Additional Text
Gene Name
ENPEP
Gene ID
2028
Uniprot ID
Q07075
Purification
Protein A purified
Concentration
1 ug/ul
Antibody Clonality
Monoclonal
Modification
Unmodified
Specificity
Aminopeptidase A antibody, AMPE_HUMAN antibody, AP-A antibody, APA antibody, bp-1 antibody, bp1 antibody, CD249 antibody, Differentiation antigen gp160 antibody, EAP antibody, Enpep antibody, Glutamyl aminopeptidase (aminopeptidase A) antibody, Glutamyl aminopeptidase antibody, Gp160 antibody, Ly51 antibody
Storage Note
Store at -20°C for 12 months.
bsm-54646R Datasheet
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