N6-Propargyl-ATP (N6pATP)
Catalogue Number: CLK-NU-001-5-JEN
| Manufacturer: | Jena Bioscience |
| Shelf Life: | 12 months |
| Molecular Formula: | C13H18N5O13P3 (free acid) |
| Physical state: | solid |
| Type: | Conjugation Reagent |
| Shipping Condition: | Blue Ice |
| Storage Condition: | RT |
| Unit(s): | 5 mg |
| Application: | Cnjg |
Additional Text
Solubility
10 mM Tris-HCl pH 7.5
Application Notes
in vitro AMPylation of proteins[1,2] in vitro polyadenylation of RNA[3] The resulting alkyne-functionalized protein[1,2] or RNA[3] can subsequently be processed via Cu(I)-catalyzed (azide-alkyne) click chemistry that offers the choiceto introduce a Biotin group for subsequent purification tasks (via Azides of Biotin)to introduce fluorescent group for subsequent microscopic imaging (via Azides of fluorescent dyes)to crosslink the RNA to azide-functionalized biomolecules e.g.proteins Presolski et al.[4] and Hong et al.[5] provide a general protocol for Cu(I)-catalyzed click chemistry reactions that may be used as a starting point for the set up and optimization of individual assays. Agonistic ligand, mainly for nucleoside receptor A1 Nucleoside-triphosphates can be converted by different membrane-bound phosphatases into nucleosides acting as nucleoside receptor ligands. In some cases nucleoside phosphates act also directly on nucleoside receptors.
Short Description
N6-Propargyl-adenosine-5'-triphosphate, Sodium salt
Smile String
O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1c2c(c(ncn2)NCC#C)nc1
Additional Information
Please note: This compound contains a phosphoramide linkage which is hydrolyzed at pH
Storage Note
store at -20 °C|12 months after date of delivery||Short term exposure (up to 1 week cumulative) to ambient temperature possible.
CLK-NU-001-5 Datasheet
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