Recombinant Human Kit ligand protein(KITLG), partial (Active)
Catalogue Number: CSB-AP002061HU-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 18.5 kDa |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Alias: | Mast cell growth factor, Stem cell factor, SCF, c-Kit ligand |
| Host Cell: | E.coli |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 ug, 100 ug, 500 ug |
Description
Description: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Additional Text
Uniprot ID
P21583
OMIN ID
145250
Protein Tag
Untagged
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