Recombinant Human Tumor necrosis factor ligand superfamily member 13B(TNFSF13B), partial (Active)

Catalogue Number: CSB-AP002191HU-CSB

Manufacturer:Cusabio Biotech
Shelf Life:6 months
Molecular Weight:17.2 kDa
Physical state:Lyophilized
Type:Cytokines
Alias:B lymphocyte stimulator, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1
Host Cell:E.coli
Shipping Condition:Blue Ice
Unit(s): 100 ug, 5 ug, 500 ug

Description

Description: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:10973284}.; Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. {ECO:0000250}.; Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis. {ECO:0000269|PubMed:10973284}.

Additional Text

Uniprot ID

Q9Y275

OMIN ID

603969

Protein Tag

Untagged

Price
£1,296.00


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