Recombinant Human B-lymphocyte antigen CD19(CD19), partial (Active)

Catalogue Number: CSB-AP005061HU-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	57.3 kDa
Physical state:	Lyophilized
Type:	Bioactive Proteins
Alias:	B-Lymphocyte Antigen CD19; B-Lymphocyte Surface Antigen B4; Differentiation Antigen CD19; T-Cell Surface Antigen Leu-12; CD19
Host Cell:	Mammalian Cells
Shipping Condition:	Blue Ice
Unit(s):	50 ug, 10 ug, 1 mg, 500 ug

Overview
Datasheets

Description

Description: CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen.

Additional Text

Uniprot ID

P15391

Biological Activity

The ED50 as determined by its ability to binding CD19 used funtional ELISA is less than 20 ug/ml

Endotoxin

Less than 1.0 EU/µg as determined by LAL method.

Function

Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

Protein Tag

Fc Tag

OMIN ID

107265

CSB-AP005061HU Sequence

Price

£391.00

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