Recombinant Guinea pig Cytotoxic T-lymphocyte associated protein 4(CTLA4), partial (Active)
Catalogue Number: CSB-AP005121GU-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 14.1 kDa |
| Physical state: | Liquid |
| Type: | Bioactive Proteins |
| Alias: | Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA-4; CD152; CTLA4 |
| Host Cell: | Yeast |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug, 10 ug, 1 mg, 500 ug |
Description
Description: Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule that is a member of the Ig superfamily.CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
Additional Text
Biological Activity
The ED50 as determined by its ability to bind Mouse B7-1 in functional ELISA is less than 0.4 ug/ml.
Endotoxin
Less than 1.0 EU/µg as determined by LAL method.
Uniprot ID
H0VUB1
Protein Tag
6xHIS Tag
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