Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9), partial (Active)

Catalogue Number: CSB-AP005141HU-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	18.1 kDa
Physical state:	Lyophilized
Type:	Bioactive Proteins
Alias:	CD137; ILA; TNFRSF9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA
Host Cell:	Mammalian Cells
Shipping Condition:	Blue Ice
Unit(s):	50 ug, 10 ug, 1 mg, 500 ug

Overview
Datasheets

Description

Description: Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necrosis factor receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. CD137 is expressed by mesenchymal cells, including endothelial cells, chondrocytes, and cells of the central nervous system. CD137 is also broadly expressed by cells of the human immune system, is broadly expressed by cells of the human immune system, including activated CD8+ and CD4+ T cells, activated natural killer (NK) cells, follicular dendritic cells (FDCs) and monocytes. CD137 has diverse roles in the immune response, the one key function is to promote the survival of both T cells and dendritic cells by binding the cognate ligand CD137L (4-1BBL).

Additional Text

Uniprot ID

Q07011

Biological Activity

The ED50 as determined by its ability to bind Human TNFSF9 in functional ELISA is less than 50 ug/ml.

Endotoxin

Less than 1.0 EU/µg as determined by LAL method.

Function

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

OMIN ID

602250

Protein Tag

6xHIS Tag

CSB-AP005141HU Sequence

Price

£223.00

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