Recombinant Human Tumor necrosis factor receptor superfamily member 9(TNFRSF9), partial (Active)
Catalogue Number: CSB-AP005151HU-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 44.2 kDa |
| Physical state: | Lyophilized |
| Type: | Bioactive Proteins |
| Alias: | CD137; ILA; TNFRSF9; 4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA |
| Host Cell: | Mammalian Cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug, 10 ug, 1 mg, 500 ug |
Description
Description: Tumor necrosis factor receptor superfamily member 9(TNFRSF9), also known as CD137 and 4-1BB, is an inducible T cell surface protein belonging to the tumor necrosis factor receptor superfamily. It is a single-pass type I membrane protein which contains 4 TNFR-Cys repeats. The human and mouse proteins share 60% amino acid sequence identity. CD137 is expressed by mesenchymal cells, including endothelial cells, chondrocytes, and cells of the central nervous system. CD137 is also broadly expressed by cells of the human immune system, is broadly expressed by cells of the human immune system, including activated CD8+ and CD4+ T cells, activated natural killer (NK) cells, follicular dendritic cells (FDCs) and monocytes. CD137 has diverse roles in the immune response, the one key function is to promote the survival of both T cells and dendritic cells by binding the cognate ligand CD137L (4-1BBL).
Additional Text
Uniprot ID
Q07011
Biological Activity
The ED50 as determined by its ability to bind Human TNFSF9 in functional ELISA is less than 20 ug/ml.
Endotoxin
Less than 1.0 EU/µg as determined by LAL method.
Function
Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Protein Tag
Fc Tag
OMIN ID
602250
CSB-AP005151HU Sequence
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations