Recombinant Human T-lymphocyte activation antigen CD86(CD86), partial (Active)

Catalogue Number: CSB-AP005161HU-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	26.69 kDa
Physical state:	Lyophilized
Type:	Bioactive Proteins
Alias:	T-Lymphocyte Activation Antigen CD86; Activation B7-2 Antigen; B70; BU63; CTLA-4 Counter-Receptor B7.2; FUN-1; CD86; CD28LG2
Host Cell:	Mammalian Cells
Shipping Condition:	Blue Ice
Unit(s):	50 ug, 10 ug, 1 mg, 500 ug

Overview
Datasheets

Description

Description: The protein is the receptor that involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. The protein interacts with MARCH8, human herpesvirus 8 MIR2 protein, adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.It contains 1 Ig-like C2-type(immunoglobulin-like) domainand 1 Ig-like V-type (immunoglobulin-like) domain.

Additional Text

Uniprot ID

P42081

Biological Activity

The ED50 as determined by its ability to bind Human CTLA-4 in functional ELISA is less than 20 ug/ml.

Endotoxin

Less than 1.0 EU/µg as determined by LAL method.

Function

Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.; FUNCTION

OMIN ID

601020

Protein Tag

6xHIS Tag

CSB-AP005161HU Sequence

Price

£186.00

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Quantity
Unit Size

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