Recombinant Human Tumor necrosis factor receptor superfamily member 5(CD40), partial (Active)
Catalogue Number: CSB-AP005181HU-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 46.3 kDa |
| Physical state: | Lyophilized |
| Type: | Bioactive Proteins |
| Alias: | Tumor Necrosis Factor Receptor Superfamily member 5; B-Cell Surface Antigen CD40; Bp50; CD40L Receptor; CDw40; CD40; TNFRSF5 |
| Host Cell: | Mammalian Cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug, 10 ug, 1 mg, 500 ug |
Description
Description: CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction. CD40 plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.
Additional Text
Uniprot ID
P25942
Biological Activity
The ED50 as determined by its ability to bind Human TNFSF5 in functional ELISA is less than 20 ug/ml.
Endotoxin
Less than 1.0 EU/µg as determined by LAL method.
Function
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
Protein Tag
Fc Tag
OMIN ID
109535
CSB-AP005181HU Sequence
SUPPORT
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PRODUCT
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DELIVERY
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