Recombinant Human Tumor necrosis factor receptor superfamily member 4(TNFRSF4), partial (Active)
Catalogue Number: CSB-AP005241HU-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 21 kDa |
| Physical state: | Lyophilized |
| Type: | Bioactive Proteins |
| Alias: | Tumor necrosis factor receptor superfamily member 4;TNFRSF4;OX40;CD134;Txgp1 |
| Host Cell: | Mammalian Cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug, 10 ug, 1 mg, 500 ug |
Description
Description: OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
Additional Text
Uniprot ID
P43489
Biological Activity
The ED50 as determined by its ability to bind Human TNFSF4 in functional ELISA is less than 25 ug/ml.
Endotoxin
Less than 1.0 EU/µg as determined by LAL method.
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
OMIN ID
600315
Protein Tag
6xHIS Tag
CSB-AP005241HU Sequence
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
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