Recombinant Human Tumor necrosis factor receptor superfamily member 4(TNFRSF4), partial (Active)

Catalogue Number: CSB-AP005241HU-CSB

Manufacturer:Cusabio Biotech
Shelf Life:6 months
Molecular Weight:21 kDa
Physical state:Lyophilized
Type:Bioactive Proteins
Alias:Tumor necrosis factor receptor superfamily member 4;TNFRSF4;OX40;CD134;Txgp1
Host Cell:Mammalian Cells
Shipping Condition:Blue Ice
Unit(s): 50 ug, 10 ug, 1 mg, 500 ug

Description

Description: OX40, also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.

Additional Text

Uniprot ID

P43489

Biological Activity

The ED50 as determined by its ability to bind Human TNFSF4 in functional ELISA is less than 25 ug/ml.

Endotoxin

Less than 1.0 EU/µg as determined by LAL method.

Function

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.

OMIN ID

600315

Protein Tag

6xHIS Tag

Price
£354.00


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