Recombinant Human Hepatitis A virus cellular receptor 2(HAVCR2), partial (Active)
Catalogue Number: CSB-AP005291HU-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 47.7 kDa |
| Physical state: | Lyophilized |
| Type: | Bioactive Proteins |
| Alias: | Hepatitis A virus cellular receptor 2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell membrane protein 3; FLJ14428;KIM-3;Tim-3;TIM3;TIMD3 |
| Host Cell: | Mammalian Cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug, 10 ug, 1 mg, 500 ug |
Description
Description: Hepatitis A virus cellular receptor 2 (HAVCR2) is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Additional Text
Uniprot ID
Q8TDQ0
Biological Activity
The ED50 as determined by its ability to bind Human Galectin-9 in functional ELISA is less than 20 ug/ml.
Endotoxin
Less than 1.0 EU/µg as determined by LAL method.
Function
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand
OMIN ID
606652
Protein Tag
6xHIS-Fc Tag
CSB-AP005291HU Sequence
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