Recombinant Mouse Hepatitis A virus cellular receptor 2 homolog(Havcr2), partial (Active)

Catalogue Number: CSB-AP005341MO-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	46.3 kDa
Physical state:	Lyophilized
Type:	Bioactive Proteins
Alias:	Hepatitis A virus cellular receptor 2 homolog; HAVcr-2; T-cell immunoglobulin and mucin domain-containing protein 3; T-cell immunoglobulin mucin receptor 3; T-cell membrane protein 3; Tim3; Timd3
Host Cell:	Mammalian Cells
Shipping Condition:	Blue Ice
Unit(s):	50 ug, 10 ug, 1 mg, 500 ug

Overview
Datasheets

Description

Description: T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.

Additional Text

Biological Activity

The ED50 as determined by its ability to bind Human Galectin 9 in functional ELISA is less than 20 ug/ml.

Endotoxin

Less than 1.0 EU/µg as determined by LAL method.

Function

Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand

Uniprot ID

Q8VIM0

Protein Tag

Fc Tag

CSB-AP005341MO Sequence

Price

£223.00

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