Recombinant Human Calcium-activated potassium channel subunit alpha-1 (KCNMA1), partial

Catalogue Number: CSB-EP614255HU-CSB

Manufacturer:Cusabio Biotech
Shelf Life:6 months
Molecular Weight:20.0 kDa
Physical state:Liquid or Lyophilized powder
Type:Fusion Protein
Alias:BK channel (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo) (KCNMA) (SLO)
Host Cell:E.coli
Shipping Condition:Blue Ice
Unit(s): 1 mg, 100 ug, 20 ug

Description

Description: Potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. It is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca2+, caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin and charybdotoxin.

Additional Text

Uniprot ID

Q12791

OMIN ID

600150

Protein Tag

6xHIS-HPC4-Tag

Price
£1,581.00


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