Recombinant Human Epidermal growth factor receptor(EGFR), partial (Active)

Catalogue Number: CSB-MP007479HU-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	73.6 kDa
Physical state:	Lyophilized
Type:	Protein Kinases
Alias:	Proto-oncogene c-ErbB-1 (Receptor tyrosine-protein kinase erbB-1 ) (ERBB) (ERBB1) (HER1)
Host Cell:	Mammalian Cells
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug, 1 mg

Overview

Description

Description: Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Plays a role in enhancing learning and memory performance.Isoform 2 may act as an antagonist of EGF action. Acts as a receptor for hepatitis C virus in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.

Additional Text

Uniprot ID

P00533

OMIN ID

131550

Protein Tag

10xHIS Tag, Myc Tag

Price

£274.00

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