Recombinant Human NKG2-D type II integral membrane protein(KLRK1), partial (Active)

Catalogue Number: CSB-MP012474HU1-CSB

Manufacturer:Cusabio Biotech
Shelf Life:6 months
Molecular Weight:43.6 kDa
Physical state:Lyophilized
Type:Bioactive Proteins
Alias:Killer cell lectin-like receptor subfamily K member 1 (NK cell receptor D) (NKG2-D-activating NK receptor) (CD314)
Host Cell:Mammalian Cells
Shipping Condition:Blue Ice
Unit(s): 100 ug, 20 ug, 1 mg

Description

Description: Function as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8+ T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.

Additional Text

Uniprot ID

P26718

Protein Tag

hFC Tag

Price
£274.00


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