TAP2 Antibody
Catalogue Number: CSB-PA22539A0RB-CSB
CSB-PA22539A0RB Image
CSB-PA22539A0RB Image
CSB-PA22539A0RB Image
IHC image of CSB-PA22539A0Rb diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
CSB-PA22539A0RB Image
IHC image of CSB-PA22539A0Rb diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
| Manufacturer: | Cusabio Biotech |
| Preservative: | 0.03% ProClin™ 300 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant Human Antigen peptide transporter 2 protein (473-615AA) |
| Application: | ELISA, IHC |
Description
Description: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Additional Text
Gene Name
TAP2
Uniprot ID
Q03519
Purification
Protein G purified
Gene ID
6891
Antibody Clonality
Polyclonal
Specificity
ABC transporter, MHC 2 antibody; ABC18 antibody; ABCB3 antibody; Antigen peptide transporter 2 antibody; APT2 antibody; ATP binding cassette, sub family B (MDR/TAP), member 3 antibody; ATP-binding cassette sub-family B member 3 antibody; D6S217E antibody; Peptide supply factor 2 antibody; Peptide transporter involved in antigen processing 2 antibody; Peptide transporter PSF2 antibody; Peptide transporter TAP2 antibody; PSF 2 antibody; PSF-2 antibody; PSF2 antibody; Really interesting new gene 11 protein antibody; RING 11 antibody; RING11 antibody; TAP 2 antibody; Tap2 antibody; TAP2_HUMAN antibody; Transporter 2 ATP binding cassette sub family B antibody; Transporter 2, ABC (ATP binding cassette antibody; Transporter 2, ATP binding cassette, sub family B (MDR/TAP) antibody
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
we offer free delivery to UK universities and non profit organisations