RIPA-56

Catalogue Number: CV-1043-2-RPE

Manufacturer:rPeptide
Physical state:Lyophilized
Type:Kinase Inhibitors
Shipping Condition:RT
Unit(s): 50 mg

Description

Description: RIPA-56 is a potent (IC50=13 nM, EC50=28 nM for HT-29 cells) and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with significant metabolic stability (t1/2=128 min human liver microsomal stability assay). RIPA-56 showed excellent kinase selectivity and did not inhibit IDO at 200 µM. It was able to block the progression of multiple sclerosis in an immune-induced demyelination model.