Anti-CD31 (Ms,Sw) from Rat (SZ31) for mouse FFPE tissue
Catalogue Number: DIA-310-DIA
| Manufacturer: | Dianova |
| Preservative: | 0.05% Sodium azide |
| Physical state: | Lyophilized |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | Platelet endothelial cell adhesion molecule;PECAM-1;EndoCAM;GPIIA';PECA1;CD31;PECAM1;Platelet/Endothelial Cell Adhesion Molecule 1;Platelet/Endothelial Cell Adhesion Molecule;Pecam1;Pecam;Pecam-1 |
| Shipping Condition: | RT |
| Storage Condition: | 2-8°C |
| Unit(s): | 0.5 ml |
| Host name: | Rat |
| Clone: | SZ31 |
| Isotype: | IgG2a |
| Immunogen: | Murine amino acid fragment (amino acids 610-681 of mouse CD31) |
| Application: | IHC-P, WB, IHC |
Description
Description: Antibody clone SZ31 is the first antibody which reacts specifically with murine CD31 in formalin-fixed paraffin-embedded tissue sections. Clone SZ31 shows no cross-reactivity to human CD31. Outstanding specificity of clone SZ31 has been confirmed in more than 200 citations (CiteAB). CD31, also known as PECAM-1 (Platelet Endothelial Cell Adhesion Molecule-1) is expressed constitutively on the surface of embryonic and adult endothelial cells. It is also expressed on cell surfaces of monocytes, neutrophils, platelets and certain T-cell subsets. It has been detected on bone marrow-derived hematopoetic stem cells and embryonic stem cells. Cluster of Differentiation 31 (CD31) is a 130kDa integral membrane glycoprotein and as a member of the immunoglobulin superfamily involved in the mediation of cell-to-cell adhesion. CD31-mediated endothelial cell-cell interactions play a major role in angiogenesis. Studies have shown CD31 to be a superior marker in human angiogenesis, which reportedly predicts tumor recurrence. Pathophysiological studies of CD31 in murine model systems had limitations because standard formalin-fixed sections were excluded. The clone SZ31 (Anti-CD31) eliminates these restrictions by allowing high quality immunohistochemical analysis of standard formalin-fixed paraffin sections in mice.
Additional Text
Gene Name
PECAM1
Gene ID
18613
Uniprot ID
Q08481
Purification
Purified
Antibody Clonality
Monoclonal
DIA-310 Reference
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