Anti-p53 (Hu) from Mouse (Clone: CC53)
Catalogue Number: DIA-530-P05-DIA
| Manufacturer: | Dianova |
| Preservative: | 0.05% Sodium azide |
| Physical state: | Lyophilized |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | P53;Cellular Tumor Antigen P53;P53 Tumor Suppressor;Tumor Protein p53;TP53;Tumor Protein;Tumor Suppressor P53;LFS1;Transformation related protein 53;TRP53;Li-Fraumeni Syndrome;Antigen NY-CO-13 |
| Shipping Condition: | RT |
| Storage Condition: | 2-8°C |
| Unit(s): | 0.5 ml |
| Host name: | Mouse |
| Clone: | CC53 |
| Isotype: | IgG1 |
| Immunogen: | Recombinant human wild type p53 protein |
| Application: | ICC, IHC-P, IHC |
Description
Description: The p53 tumor suppressor gene has been found to contain mutations in over 50% of human cancers. Many mutations of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 immunostaining is of use in demonstrating accumulation of p53 protein, which occurs in a high frequency in a wide variety of transformed cells. Anti-p53 Tumor Suppressor Protein antibody recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene product. It reacts with the mutant as well as wild form of p53. Positive nuclear staining with this antibody has been shown to be a negative prognostic factor in Breast carcinoma, Lung carcinoma, Colorectal, and Urothelial carcinoma. p53 positivity has also been used to differentiate Uterine serous carcinoma from endometrioid carcinoma as well as to detect Intratubular germ cell neoplasia. Moreover antibody clone CC53 helps to detect single invading astrocytoma-cells.
Additional Text
Gene Name
TP53
Gene ID
7157
Uniprot ID
P04637
Purification
Purified
Antibody Clonality
Monoclonal
DIA-530-P05 Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations