(KO Validated) BCL10 Polyclonal Antibody
Catalogue Number: E-AB-60188-ELA
E-AB-60188 Image
E-AB-60188 Image
E-AB-60188 Image
Western blot analysis of extracts from normal (control) and BCL10 knockout (KO) HeLa cells using BCL10 Polyclonal Antibody at dilution of 1:1000.
E-AB-60188 Image
Western blot analysis of extracts of various cell lines using BCL10 Polyclonal Antibody at dilution of 1:1000.
| Manufacturer: | Elabscience |
| Preservative: | 0.02% Sodium azide |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Alias: | BCL10,CARMEN,CIPER,CLAP,IMD37,c-E10,mE10 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 120 ul, 200 ul, 60 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant fusion protein of human BCL10 (NP_003912.1). |
| Application: | WB |
Description
Description: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants.
Additional Text
Gene Name
BCL10
Concentration
1 mg/ml
Gene ID
8915
Uniprot ID
O95999
Purification
Affinity Purified
Antibody Clonality
Polyclonal
Store at -20°C. Avoid freeze / thaw cycles.
E-AB-60188 Protocol
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations