Catalogue Number: E-AB-F1137L-ELA
Manufacturer: | Elabscience |
Preservative: | 0.05% ProClin™ 300 |
Type: | Monoclonal Primary Antibody - Conjugated |
Alias: | Receptor-type tyrosine-protein phosphatase C,Ptprc,L-CA,Ly-5,T200,CD45 |
Shipping Condition: | Blue Ice |
Unit(s): | 100 tests, 20 tests, 200 tests |
Host name: | Mouse |
Clone: | HI30 |
Isotype: | IgG1, kappa |
Immunogen: | |
Application: | FC |
Description: CD45 is a 180 - 240 kD single chain type I membrane glycoprotein also known as leukocyte common antigen (LCA) and T200. It is a tyrosine phosphatase expressed on the plasma membrane of all hematopoietic cells, except erythrocytes or platelets. CD45 is a signaling molecule that regulates a variety of cellular processes including cell growth, differentiation, cell cycle, and oncogenic transformation. CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to bind galectin-1 and to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4.
PTPRC
5788
P08575
Monoclonal
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.