APC Anti-Mouse IL-17A Antibody[TC11-18H10.1]
Catalogue Number: E-AB-F1199E-ELA
| Manufacturer: | Elabscience |
| Preservative: | 0.05% ProClin™ 300 |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | Interleukin-17A,IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8,CTLA8 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests, 200 tests, 50 tests |
| Host name: | Rat |
| Clone: | TC11-18H10.1 |
| Isotype: | IgG1, kappa |
| Immunogen: | |
| Application: | FC |
Description
Description: IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including: the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases. Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.
Additional Text
Gene Name
IL17A
Gene ID
16171
Uniprot ID
Q62386
Antibody Clonality
Monoclonal
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
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