APC Anti-Mouse Foxp3 Antibody[3G3]
Catalogue Number: E-AB-F1238E-ELA
E-AB-F1238E Image
E-AB-F1238E Image
C57BL/6 splenocytes are surface stained with FITC Anti-Mouse CD4 Monoclonal Antibody followed by fixation and permeabilization using the Foxp3 Staining/Transcription Factor Buffer Set and intracellular staining with APC Anti-Mouse Foxp3 Monoclonal Antibody.
| Manufacturer: | Elabscience |
| Preservative: | 0.05% ProClin™ 300 |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Alias: | Forkhead box protein P3,IPEX,JM2,Foxp3 |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 tests, 200 tests, 50 tests |
| Host name: | Mouse |
| Clone: | 3G3 |
| Isotype: | IgG1, kappa |
| Immunogen: | |
| Application: | FC |
Description
Description: FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.
Additional Text
Uniprot ID
Q99JB6
Antibody Clonality
Monoclonal
Gene ID
20371; 317382; 50943
Gene Name
Foxp3, FOXP3
Store at 2~8°C and protected from prolonged exposure to light. Do not freeze.
E-AB-F1238E Protocol
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