STEALTH Liposomal Topotecan HCl (2.0mg/mL)
Catalogue Number: F30204-TT-FOR
| Manufacturer: | FormuMax |
| Type: | Liposome |
| Alias: | STEALTH Liposomal Topotecan HCl (2.0mg/mL) (F30204-TT) |
| Shipping Condition: | Blue Ice |
| Storage Condition: | 2-8°C |
| Unit(s): | 2 ml, 10 ml |
Description
Description: PEGylated Liposomal Topotecan HCl Topotecan HCl is loaded into PEGylated liposomes composed of HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) with ammonium sulfate gradient by the active loading approach. The liposomes are produced by the extrusion method. The product is of high quality with narrow particle size distribution and high drug encapsulation efficiency. Product For Research only and NOT for Human Use Specifications Product code: F30204-TT Lipid composition: HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Lipid concentration: 20.0 mM Topotecan HCl: 2.0 mg/mL Encapsulation efficiency: > 95% Loading battery: 250 mM ammonium sulfate Mean particle size: 100 nm (80-110 nm) External solution: 10% sucrose, 20 Mm HEPES, pH 7.0 Shelf-life: 3 months, storage: 2-8 degree C Topotecan: Synonym: 9-,Aea[(dimethylamino),Aeamethyl],Aea-,Aea10-,Aeahydroxy-,Aea(20S),Aea-,Aeacamptothecin hydrochloride hydrate CAS Number: 123948-87-8 (free base) HSPC: hydrogenated phosphatidylcholine (Soy) CHOL: cholesterol mPEG2000-DSPE: 18:0 PEG2000 PE:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]
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