Phos binding reagent (Phosbind) acrylamide

Catalogue Number: F4002-APE

Manufacturer:	Apexbio
Molecular Formula:	C33H38N8O3
Type:	Other Reagents
Shipping Condition:	Blue Ice
Storage Condition:	2-8°C
Unit(s):	10 mg, 5 mg, 50 mg

Overview
Datasheets

Description

Description: Protein phosphorylation is an important covalent post-translational modification that can alter the structural conformation of a protein, which then regulates the function, location and specific binding of the target protein. Many cellular processes are regulated by the reversible phosphorylation of proteins and 30% of the proteins are likely to be phosphorylated at some point during their existence.The determination of the phosphorylation state of proteins is important for defining protein kinase substrates and revealing the activation state of signal transduction pathways. Methods for determining the phosphorylation status of proteins are thus have important implications in the understanding of diverse biological and pathophysiological processes, such as signal transduction pathways, cancer and other diseases.Phos binding reagents (Phosbind) are specific and selective phosphate-binding reagents, and exhibit preferential ionic interactions with phosphorylated ions on phosphorylated proteins or peptides at neutral pH. Phos binding reagent is a dinuclear metal (Zn2+ or Mn2+) complex.Phosbind Acrylamide is a specific reagent for separation of phosphorylated proteins using SDS-PAGE method.

Additional Text

Solubility

>29.7mg/mL in DMSO

Short Description

Separation of phosphorylated and non-phosphorylated proteins

Storage Note

2-10°C

F4002 CofA

F4002 MSDS

Price

£400.00

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